Side effects of cisplatin cisplatin injection, warnings, uses. Following completion of platinumbased therapy, treatment with alimta with or without pembrolizumab isadministered until disease progression or unacceptable toxicity. If youre enrolled in a medicare advantage plan or medicare prescription drug. Cisplatin is also being studied in the treatment of other types of cancer. Cisplatin, cisplatinum, or cisdiamminedichloroplatinumii cddp is a platinumbased chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas e. This study is created by ehealthme based on reports of 60,869 people who have side effects when taking cisplatin from the food and drug administration fda. Withhold or discontinue imfinzi to manage adverse reactions as described in table 2. Cisplatin works by damaging the dna inside the cancer cells which prevents them from dividing. Appropriate management of therapy and complications is possible only when adequate diagnostic and treatment facilities are readily available.
Cisplatin, the active ingredient in cisplatin for injection, usp, is a yellow to orange crystalline powder with the molecular formulacl 2 h 6 n 2 pt and a molecular weight of 300. Each 50 ml or 100 ml amber vial of infusion concentrate contains. The discovery and development of cisplatin article pdf available in journal of chemical education 835 may 2006 with 4,548 reads how we measure reads. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is. Patients treated with pemetrexed for injection plus cisplatin received a relative dose intensity of 94. Cisplatin belongs to the group of medicines known as alkylating agents. A drug list, or formulary, is a list of prescription drugs covered by your plan. It is also used together with other drugs to help treat testicular cancer, locally advanced squamous cell carcinoma of the head and neck, late stage cervical cancer, malignant mesothelioma, and nonsmall cell lung cancer. The information included in this section describes the potential hazards of the individual ingredients. Cisplatin is a medicine used alone or with other therapies to treat cancer of the testicles, ovaries, or bladder the drug is also sometimes used offlabel to treat head and neck. Is there any good replacement drug for cisplatin as a. Cisplatin is a heavy metal complex containing a central atom of platinum surrounded by two chloride atoms and two ammonia molecules in the cis position.
Cisplatin interferes with the growth of cancer cells, which are eventually destroyed. Cisplatin hydration for outpatients chemotherapy regimen. Cisplatin injection is a sterile aqueous solution, available in 50 and 10 ml single dose vials where each ml contains 1 mg of cisplatin and 9 mg sodium chloride in sterile water for injection. View the current policies that apply to unitedhealthcare commercial benefit plans. The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. May 28, 2019 hypersensitivity to cisplatin or to any of the excipients listed in section 6. Medlineplus information on cisplatin a lay language summary of important information about this drug that may include the following. Oct 05, 2014 cisplatin has a molecular weight of 301. Potentiation of cisplatinbased chemotherapy by digoxin in. Join aarp today receive access to exclusive information. Prescribing and technical information pembrolizumab for untreated pdl1positive locally advanced or metastatic urothelial cancer when cisplatin is unsuitable guidance ta522. Highlights of prescribing information these highlights do not include all the information needed to use gemzarsafely and effectively. Hindpaw mechanical hypersensitivity for at least 15 days after.
Higher doses of cisplatin are being given in daycare, increasing the strain on the chemotherapy suites and pharmacy. Each 50 ml or 100 ml amber vial of cisplatin injection contains. Aug 06, 2019 cisplatin, the active ingredient in cisplatin injection, usp, is a yellow to orange crystalline powder with the molecular formula cl 2 h 6 n 2 pt and a molecular weight of 300. Cisplatin is fda approved for other cancers and has been shown to be an active treatment for breast cancer. Cisplatin platinol and vincristine oncovin used to treat bladder. Highlights of prescribing information taxotere safely. This leaflet answers some common questions about cisplatin injection.
Cisplatin injection is a clear, lightyellow, sterile aqueous solution available in amber vials containing 1 mgml of cisplatin. Cisplatin requires intensive intravenous hydration. Patients meeting all inclusion exclusion criteria, will be given 3 cycles of the following regimen. Hci andor sodium hydroxide may be added to adjust the ph to 3. See full prescribing information for complete boxed warning. Taxotere in combination with cisplatin and fluorouracil is indicated for the induction treatment of patients with locally advanced squamous cell carcinoma of the head and neck scchn.
The policies and protocols presented here may not apply to all unitedhealthcare plans. This library includes unitedhealthcare policies and protocols. Peyrone in 1844 and its chemical structure was first elucidated by alfred werner in 1893. His cisplatin was pulled after the first dose due to hearing loss. Cisplatin dosing, indications, interactions, adverse effects.
Platinol cisplatin for injection, usp should be administered under the supervision. Indications, dose, contraindications, sideeffects, interactions, cautions, warnings and other safety information for cisplatin. Jul 24, 2015 cisplatin is a prescription medicine used alone to treat bladder and ovarian cancer. May use concomitant amifostine to decrease nephrotoxicity. Jul 18, 2017 cisplatin injection cisplatin injection cisplatin cisplatin injection injection is a sterile aqueous solution, available in 50, 100 and 200 ml multiple dose vials, each ml containing 1 mg of cisplatin cisplatin injection and 9 mg sodium chloride in water for injection. Cisplatin is a heavy metal complex containing a central. Cisplatin is prescribed for the treatment of various types of cancer, including ovarian cancer, testicular cancer, and bladder cancer. Azd1775 is a drug that is designed to block a protein called wee1 which may control the ability of certain cancer cells to grow or divide. Gemzar gemcitabinefor injection, for intravenous use initial u. It does not take the place of talking to your doctor or pharmacist. Cisplatin injection cisplatin injection cisplatin cisplatin injection injection is a sterile aqueous solution, available in 50, 100 and 200 ml multiple dose vials, each ml containing 1 mg of cisplatin cisplatin injection and 9 mg sodium chloride in water for injection. Hypersensitivity to cisplatin or to any of the excipients listed in section 6. Severe renal toxicities are doserelated and cumulative.
In order to for patients to be treated as a day case, the regimens have been modified as follows. View the current policies that apply to unitedhealthcare and affiliated medicare advantage benefit plans. Replacement of cisplatin with carboplatin in combination. See the medicare benefit policy manual, chapter 15, 50. Nephrotoxicity doserelated and cumulative renal insufficiency is the major doselimiting toxicity of cisplatin. These solutions are stable up to 24 hours at room temperature. Pemetrexed fda prescribing information, side effects and. This chemotherapy medication is designed to kill cancer cells and normal cells by causing abnormal linkages in dna.
Cisplatin cisplatin dose, indications, adverse effects. It is paramount for health care practitioners managing such patients to be aware of cisplatins ototoxic properties and the clinical signs to identify. Prescription and overthecounter drugs that may hurt. The related drug information index provides comprehensive access to all drug information related to a specific drug types of content include full prescribing information, drug summaries, full prescribing information continuing medication education full pi cme, medication guides, risk evaluation and mitigation strategies rems summaries, rems continuing medication education rems cme, and.
Cisplatin for injection is contraindicated in patients with severe hypersensitivity to cisplatin see warnings and precautions. Dose adjustment for gemcitabine for injection in combination with carboplatin for subsequent cycles is based upon observed toxicity. Use is contraindicated in those patients with a history of allergic reaction to cisplatin or other platinum containing compounds, or any component of the formulation. Renal toxicity has been noted in 28% to 36% of patients treated with a single dose of 50 mgm 2. Platinol cisplatin for injection, usp should be administered under the supervision of a qualified physician experienced in the use of cancer chemotherapeutic agents. If you get pregnant while taking cisplatin or within 14 months after your last dose, call your doctor right away. Refer to the carboplatin prescribing information for additional information. Cisplatin injection cisplatin drug medicine information. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you.
P contraindicated in pregnancy l contraindicated in lactation. Nephrotoxicity, peripheral neuropathy, nausea and vomiting and myelosuppression. Cisplatin hydration guidelines for outpatients introduction there is increasing demand to treat more patients as outpatients. It is used to treat cancer of the bladder, ovaries, and testicles. In the interior of cells, chloride atoms in cisplatin are replaced by water molecules.
For dosing modifications for cisplatin, carboplatin, or pembrolizumab, refer to their prescribing information. Cisplatin fda prescribing information, side effects and uses. The benefit information in this coverage summary is based on existing national. Highlights of prescribing information history of severe. It turns out that more than 450 drugs some prescription only, others over the. Please refer to the full prescribing information for pembrolizumab and for. Cisplatin is used to treat various types of cancer. Cellular toxicity cisplatin is a potent cellular toxin, particularly in a lowchloride environment. Cisplatin injection infusion concentrate is a clear, colorless, sterile aqueous solution available in amber vials. This product information is intended only for residents of the united states. Carboplatin and taxol are also very effective chemos for what he had. Pricing, sizing, legal catgories and other medicinal forms information for cisplatin. Cisplatin is a prescription medicine used alone to treat bladder and ovarian cancer. Gemzar in combination with cisplatin is indicated for the firstline treatment of patients with.
Cisplatin supplier cas 15663271 cddp tocris bioscience. It may also be used to treat other kinds of cancer, as determined by your doctor. Cisplatin by injection national library of medicine. Highlights of prescribing information these highlights do. Hci andor sodium hydroxide added to adjust ph to 3.
Use birth control to prevent pregnancy while taking cisplatin and for 14 months after your last dose. Save money on your platinolaq injection prescription by switching to tevas fdaapproved generic version, cisplatin injection. Cisplatin injection is a clear, colorless to pale yellow, sterile aqueous solution. To minimize cisplatin resistance, combinatorial therapies were. Treatment may be complicated by severe nausea and vomiting. Refer to the dosage modifications recommendations for nonhematologic. Replacement of cisplatin with carboplatin in combination chemotherapy against ovarian cancer. This hydrolysis product is believed to be the active species, reacting with glutathione in the cytoplasm and dna in the nucleus. Cisplatin is an effective drug used in the treatment of many cancers, yet its ototoxic potential places cancer patients, exposed to this drug, at risk of hearing loss, thus negatively impacting further on a patients quality of life. Jun 01, 2015 cisplatin injection is a clear, lightyellow, sterile aqueous solution available in amber vials containing 1 mgml of cisplatin. Cisplatin vial side effects by likelihood and severity webmd. Platinol cisplatin for injection, usp is a white to light yellow lyophilized powder. Cisplatin, the active ingredient in cisplatin injection, usp, is a yellow to orange crystalline powder with the molecular formula cl 2 h 6 n 2 pt and a molecular weight of 300.
Member benefits download pdf of benefits aarp auto buying program hot deals. Cisplatin side effects, uses, dosage, overdose, pregnancy. Cisplatin is compatible in solutions containing an adequate amount of chloride ions and is incompatible with solutions having low concentrations of these ions. The dose of gemcitabine for injection in subsequent cycles should be reduced to 800 mgm2 on days 1 and 8 in case of any of the following hematologic toxicities. Definition from the nci drug dictionary detailed scientific definition and other names for this drug. Consult your healthcare professional before using this drug. Cisplatin side effects, dosage, interactions drugs. Numerous mechanisms of cisplatin resistance were described including changes in cellular uptake, drug efflux, increased detoxification, inhibition of apoptosis and increased dna repair. Cisplatin any ways is blamed for nephrotoxicity and at higher doses as dr. Ensure adequate hydration and monitor renal function and electrolytes.
Enzmann mentioned, using oxaliplatin is better as it has been approved more recently by the fda among the tin family drugs. Cisplatin 1 mgml sterile concentrate summary of product. Prescription drug plan, which are not covered in this coverage summary. Cisplatin is also sometimes used to treat head and neck cancer including cancer of the mouth, lip, cheek, tongue, palate, throat, tonsils, and sinuses, lung cancer, cancer of the cervix and esophagus, brain tumors, malignant pleural mesothlioma cancer in the lining of the chest or abdomen, and neuroblastoma a cancer that begins in nerve cells and occurs mainly in children.
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